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Preclinical Data Suggests CBD Mitigates Age-Related Cognitive Decline

Preclinical Data Suggests CBD Mitigates Age-Related Cognitive Decline

“It is possible that the effects of CBD treatment can be enhanced if an extract with THC and terpenoids is used.“


The daily administration of CBD is associated with improved memory and reduced age-related cognitive decline, according to preclinical data published in the journal Frontiers in Aging Neuroscience.

Canadian researchers assessed the effects of CBD on memory impairment and brain inflammation in older mice. Animals in the study were administered CBD daily for a period of seven months. 

Researchers reported that CBD treatment reduced neuroinflammation and improved learning and memory processes. 

“The findings of this study indicate that CBD reduces inflammatory response in the brain and improves cognitive decline associated with aging,” the study’s authors concluded.

“Importantly, evidence was also observed suggesting that long-term CBD treatments do not have negative impacts on these same functions and brain regions, nor do they cause negative side effects in aged mice subjects. … It is possible that the effects of CBD treatment can be enhanced if an extract with THC and terpenoids is used.”

Separate data published recently in the journal Alzheimer’s Research and Therapy similarly reports that CBD treatment improves memory in preclinical models of Alzheimer’s disease (AD). 

This brief was republished from NORML. Full text of the study, “Effects of cannabidiol on age-related cognitive decline in C57 mice,” appears in Frontiers in Aging Neuroscience.

NORML
About the author

Since its founding in 1970, NORML has provided a voice in the public policy debate for those Americans who oppose marijuana prohibition and favor an end to the practice of arresting marijuana consumers. A nonprofit public-interest advocacy group, NORML represents the interests of the tens of millions of Americans who use marijuana responsibly.